Ozomet-PG 2 Tablet

Description

Product Details

Ozomet-PG 2 Tablet ER is a combination medication containing Glimepiride (2 mg), Metformin (500 mg), and Pioglitazone (15 mg), primarily prescribed for the management of type 2 diabetes mellitus in adults. This formulation works synergistically to improve blood glucose control when diet, exercise, and monotherapy or dual therapy are insufficient.

Mechanism of Action:

• Glimepiride: A sulfonylurea that stimulates the pancreas to release more insulin, thereby lowering blood glucose levels.

• Metformin: A biguanide that reduces hepatic glucose production, decreases intestinal absorption of glucose, and enhances insulin sensitivity, leading to improved glucose uptake and utilization.

• Pioglitazone: A thiazolidinedione that increases insulin sensitivity in peripheral tissues, facilitating better glucose uptake by muscle and adipose cells.

  ---

Indications:

Ozomet-PG 2 Tablet ER is indicated for:

• Type 2 Diabetes Mellitus: To improve glycemic control in adults as an adjunct to diet and exercise, especially when previous treatments have not provided adequate blood sugar control.
  

  ---

Dosage and Administration:

• Dosage: The typical adult dose is one tablet taken once daily.

• Administration: It is advisable to take the tablet with food to minimize gastrointestinal side effects. Swallow the tablet whole with water; do not crush or chew.

  ---

Side Effects:

Common side effects may include:

• Hypoglycemia (low blood sugar levels)

• Headache

• Nausea

• Diarrhea

• Dizziness

• Vomiting

• Anemia (low red blood cell count)

• Weakness

• Sinus infection

These side effects are generally mild and transient. If they persist or become bothersome, consult your healthcare provider.

Precautions:

• Allergic Reactions: Do not use if you have known allergies to Glimepiride, Metformin, Pioglitazone, or any other components of the tablet.

• Liver and Kidney Function: Inform your doctor if you have liver or kidney impairments, as dose adjustments or alternative treatments may be necessary.

• Heart Conditions: Use with caution in patients with heart failure; Pioglitazone may cause or exacerbate congestive heart failure.

• Bladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; avoid use in patients with active bladder cancer or a history of the disease.

• Pregnancy and Breastfeeding: Consult your healthcare provider before using during pregnancy or while breastfeeding to assess potential risks and benefits.

  ---

Drug Interactions:

Ozomet-PG 2 Tablet ER may interact with other medications, potentially altering their effects. Inform your doctor about all prescription and over-the-counter drugs, as well as herbal supplements you are taking. Notable interactions include:

• Oral Contraceptives: Some may interfere with the effectiveness of Ozomet-PG 2 Tablet ER.

• Beta-Blockers: Medications like propranolol and metoprolol may mask symptoms of hypoglycemia.

• Diuretics: Such as hydrochlorothiazide and furosemide, which can increase the risk of hypoglycemia when combined with Ozomet-PG 2 Tablet ER.

  ---

Lifestyle and Dietary Recommendations:

• Diet: Maintain a balanced diet rich in whole grains, lean proteins, and vegetables. Monitor carbohydrate intake to manage blood sugar levels effectively.

• Exercise: Engage in regular physical activity, such as brisk walking or cycling, for at least 150 minutes per week to enhance insulin sensitivity and promote overall health.

• Monitoring: Regularly monitor your blood glucose levels as advised by your healthcare provider to ensure effective management of your condition.

  ---

Storage:

• Store in a cool, dry place away from direct sunlight and moisture.

• Keep out of reach of children.

  ---

Conclusion:

Ozomet-PG 2 Tablet ER is an effective combination therapy for managing type 2 diabetes mellitus by addressing multiple pathways involved in glucose regulation. Adherence to prescribed dosages, along with appropriate lifestyle modifications, can significantly improve glycemic control and reduce the risk of diabetes-related complications. Always consult your healthcare provider for personalized medical advice before starting or discontinuing any medication.